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We do not know what fraction reaches systemic circulation in humans, and "detectable GI effect" does not equal "adequate systemic bioavailability for joint repair." The acetate salt versus free acid labeling problem

Recommendations to standardise the methodology for scintigraphy include ensuring blood glucose concentrations are 20mmHg) fall in blood pressure after meals (postprandial hypotension) occurs in up to 40% of individuals with long-standing, complicated diabetes (more common than orthostatic hypotension), and is associated with more rapid gastric emptying [35]

FDA Label Davies M, Frch L, Jeppesen OK, et al