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386 The dual action of allopurinol and its metabolite, alloxanthine, inhibits xanthine oxidase, effectively catalyzing the conversion of hypoxanthine to xanthine and its subsequent conversion to uric acid

doi: 10.1111/andr.2018.6.issue-2 211 GualtieriRKalthurGBarbatoVLongobardiSDi RellaFAdigaSKet al

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This, in turn, augments airway smooth muscle contraction, increases airway reactivity and airway secretions, increases vascular permeability, decreases cholinesterase and neutral endopeptidase activities, and impairs the responsiveness of -adrenergic receptors 31