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K.VerdugoA.et al

Extreme deficits (800-1,000 calories below maintenance) are unnecessary and counterproductive because they increase muscle catabolism and metabolic adaptation

The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K

Although there have been contradictions on the supplement's ability to promote loss of weight, a study carried out on obese individuals supported the claim that L-carnitine does aid weight loss [4]