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GSTs are able to conjugate glutathione (-l-glutamyl-l-cysteinyl-glycine, GSH) to a wide range of hydrophobic and electrophilic molecules including many carcinogens, therapeutic drugs, and many products of oxidative metabolism, making them less toxic and predisposed to further modification for discharge from the cell (Fig

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Am J Med 118(5):2734 Polonsky W, Fisher L, Hessler D, Bruhn D, Best J (2011) Patient perspectives on once-weekly medications for diabetes

The first necessary step is the enzymatic removal of the glutamic acid residue from the glutathione-Mercury(II) conjugate to yield the Mercury(II)-cysteinyl-glycine conjugate