Headache Headache was reported in approximately 7% of participants in clinical trials
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Improved circulation to extremities is a less common but notable report
Pro-inflammatory cytokines, including TNF-, IL-1, IL-6, IL-7, IL-15, IL-17, IL-18, IL-23, interferon (IFN)-, granulocyte-macrophage colony-stimulating factor (GM-CSF) have been found to govern inflammation in RA occurrence
