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Thus, the following two tests can be used to confirm B12 issues on a cellular level: Homocysteine is a valid and reliable intracellular/functional marker of methylation

Neuro Endocrinol Lett 32(2):133140 Maes M, Fiar Z, Medina M et al (2012) New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways