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Why do GLP-1 medications cause digestive symptoms

We have shown that our previously reported potent and selective NSD2 degrader, UNC8732, is metabolized enzymatically and the corresponding aldehyde species effectively recruits FBXO22 to promote ternary complex formation and subsequent degradation of NSD2 (Fig

These facts tune down the potential contribution of CYP2D6 polymorphism in the clinical outcomes of both substances

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