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The pathophysiological mechanisms linking this persistence to post-COVID IBS likely involve: Sustained inflammatory responses with elevated interferon levels Expansion of activated immune cells even 8 months post-infection Intestinal dysbiosis affecting the gut-brain axis Increased intestinal permeability during and after infection These findings suggest that long-term GI symptoms after COVID-19 may stem from ongoing intestinal inflammation driven by viral persistence, rather than merely representing psychological sequelae of the acute illness

Nat Med 18:11701172

And we looked at what happened after a single injection of GLP-1, and one thing that happened was that there was a very short and very disappointing effect on insulin and glucose

Results vary among individuals