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These drugs should not be used by pregnant people, people with a personal or family history of thyroid cancer, or people with multiple endocrine neoplasia syndrome type 2

The engineering behind these multi-receptor molecules is the subject of how GLP-1 receptor biology became a drug-discovery platform, and it is the reason the pipeline looks less like a single race and more like several at once

Although the MASLD definition differs conceptually from traditional NAFLD criteria, multiple validation studies demonstrate high diagnostic concordance between both classification systems (810)