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These reactions are primarily mediated by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs), which generate major circulating metabolites such as luteolin-7-O-glucuronide and luteolin-3-O-glucuronide (Xiong et al., 2023)

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Common tests include fecal occult blood testing or fecal immunochemical testing (FIT) for occult blood, complete blood count (CBC) to check for anemia, stool studies for infection, and cross-sectional imaging such as a CT scan in select cases