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Limitations of Use Hydrocodone bitartrate and acetaminophen tablets are contraindicated in patients with: Significant respiratory depression (see WARNINGS) Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment (see WARNINGS) Known or suspected gastrointestinal obstruction, including paralytic ileus (see WARNINGS) Hypersensitivity to hydrocodone or acetaminophen (e.g., anaphylaxis) (see WARNINGS and ADVERSE REACTIONS) Hydrocodone bitartrate and acetaminophen tablets contain hydrocodone, a Schedule II controlled substance

This allows the product to be supplied in multi-dose vials and used for repeated withdrawals, in contrast to preservative-free sterile water which is intended for single use only

Exclusion criteria included any mice that showed signs of illness or distress prior to treatment, those with body weight below a certain threshold, and any that did not develop tumors by day 7 post-implantation

It may be prudent to select an inpatient program that is well equipped both in understanding the unique problems with antipsychotic drug withdrawal and also can provide comfortable, personalized assistance while withdrawing from the drug