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RNA interference in adult mice

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True irritation requiring product discontinuation presents as persistent burning or stinging lasting beyond application period, significant redness spreading beyond application zone or lasting multiple hours, swelling of eyelids or periorbital area, increased sensitivity making area uncomfortable to touch, or itching suggesting allergic response

Interestingly, it can be noted that whereas NEM pre-treatment was a common feature in the first clinical studies, more recently this use was pretty abandoned