International Journal of Molecular Sciences , 25(5), 2952
It is worth noting that Fig.3 highlights four major issues affecting the effectiveness and safety of Se-based treatments: (1) a narrow therapeutic window requiring precise dosing to avoid toxicity or ineffectiveness
28 Furthermore, lowering homocysteine levels using vitamins B 12 , B 6 , and folate has been found to markedly slow brain atrophy and cognitive decline
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