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[Abstract] J Adv Res

While our bodies produce glutathione naturally, factors like stress, diet, and aging can deplete its levels

Identification of biological functions of distinct ferroptosis subtypes To clarify the functional differences in different ferroptosis subtypes, we performed GSVA analysis and found that metabolism-related signaling pathway, oxidative phosphorylation, and the TCA cycle were significantly upregulated in Subtype 1, while DNA regulation, chemokine signaling, cytokine receptor interaction, autoimmune diseases, various immune cells pathways such as T cell receptor, B cell receptor, Nod-like receptor, natural killer cells activation, and Toll-like receptor pathway were upregulated in subtype 2(Fig

In addition, an intracellular abundance of reduced glutathione, as compared to oxidized glutathione, helps ensure healthy cell function