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Oxidative stress is a fundamental step for the development of steatohepatitis, experimentally demonstrated in the liver of knockout mice with NFR-2 / and with a deficient diet of methionine and choline for 14 days, which had a significant increase of neutrophils in the tissue, micro steatosis, and macrovascular steatosis compared with wild-type mice, and a 10-fold increase of KF- and p65 and a 5-fold increase of IL-1, mRNA, and TNF-

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