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125 GCGR knockout mice produced in one study had islet alpha-cell hyperplasia and these mice were additionally shown to have large increases of glucagon and GLP-1 levels in circulation, but interestingly they had lower plasma glucose levels throughout the day, similar insulin levels and improved glucose tolerance compared to GCGR+ control animals

10.1016/j.neuropharm.2012.07.019 Neuropharmacology 54 MandalA.DrerupC

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The number of adults diagnosed with diabetes has almost quadrupled since 1980, rising from 108 million to 422 million in 2014, according to the World Health Organization