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doi: 10.1016/j.cmet.2011.04.001 23 MacMickingJDNathanCHomGChartrainNFletcherDSTrumbauerMet al

A single dose taken together is unlikely to cause immediate harm, but timing matters long-term

Simple lifestyle changes can also make a difference

In addition, there was a modest statistically significant association for stroke/TIA and a suggestive, non-significant trend for MI, while coronary revascularization and hospitalization were not significantly reduced