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PLB, by inhibiting YTHDF1, may interfere with the the critical role of m6A modification in the translation of SLC7A5, which reduced SLC7A5 protein and inhibited the activation of the ferroptosis pathway
Dr Klapan administered the infusion and was sure to check on patients regularly throughout
All chemicals were prepared in sterile PBS (Gibco) and, if necessary, the pH was adjusted to 7.4 using Trizma base
The recipient mice were treated with tamoxifen, which leads to the activation of Cre recombinase activity and subsequent deletion of Gclc specifically in the implanted tumours (Fig
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