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In a previous phase II randomized controlled clinical study, Tivantinib, a highly selective c-Met inhibitor, improved median time to progression and OS time in patients with Met-high advanced HCC compared with placebo (Santoro et al., 2013)

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Kuilman T, Michaloglou C, Mooi WJ, Peeper DS

GLP-1 receptor agonists (semaglutide, tirzepatide) are prescription medications that produce sustained, pharmacological-level GLP-1 receptor activation