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5.3.2 Second hit theory and complication warning The second hit theory underpins this clinical phenomenon ( 6 Future perspectives Although existing nutritional and inflammatory markers have shown great clinical potential, there is still ample room for exploration in this field

As expected, hepsin / mice displayed heightened oxidative stress after APAP exposure compared to wild-type mice, indicated by a significant decrease in GSH and an increase in nitrotyrosine levels, leading to more severe liver damage and mortality

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As previously described in this review, IGF-1 and IGF-2 interactions with their receptors are modulated by IGFBPs