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(2) depleted hepatic glutathione levels and its intermediates despite unchanged level of reactive oxygen species, suggesting glutathione consumption exceeds production due to systemic oxidative stress after AKI

The approval matters because it validates a long-sought oral small-molecule route to GLP-1 agonism, with potentially major consequences for convenience, manufacturing scale, pricing, and patent strategy

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(2) Cord blood study: In the Boston Birth Cohort, higher cord blood acetaminophen metabolites were linked to increased likelihood of autism and ADHD