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However, while 16 days of L-citrulline supplementation at a daily dose of 3.4 g significantly increased plasma citrulline, arginine, and nitrite levels, and increased muscle oxygenation during moderate-intensity (70% VO 2 peak) exercise, there were no superior effects on time-to-exhaustion during high-intensity (90% VO 2 peak) exercise

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Our preliminary results demonstrate that GLP-1RA liraglutide exerts beneficial effects by improving dysglycemia and body weight, inhibiting inflammation, and modulating gut microbiota in prediabetic mice, potentially contributing to delaying or preventing the progression from prediabetes to overt diabetes

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