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Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11

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However, multiple meta-analyses published in peer-reviewed journals show no statistically significant increase in pancreatitis compared to DPP4 inhibitors or sulfonylurea comparators