Mitochondrial Dysfunction, Oxidative Stress, and Neuroinflammation: Intertwined Roads to Neurodegeneration
The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them
Back Heinrich, G, Gros, P, Lund, PK, et al (1984) 'Pre-Proglucagon Messenger Ribonucleic Acid: Nucleotide and Encoded Amino Acid Sequences of the rat pancreatic complementary deoxyribonucleic acid', Endocrinology , 115/6, 2176-81
doi: 10.1007/s13224-019-01251-1 87 CalogeroAGulloGLa VigneraSCondorelliRVaiarelliA