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Sheridan, School of Medicine, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland This article was submitted to Fungi and Their Interactions, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

RNF8 ubiquitinates RecQL4 and promotes its dissociation from DNA double strand breaks

However, it is important to note that FOXO plays an important role in the lifespan of C elegans, which exists as an adult organism exclusively of post-mitotic cells and lacks adult stem cells and regenerative potential

Treatment guidelines typically suggest adding a new agent instead of switching, particularly if the initial medication provided some benefit [87,188,189,190]