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79 MDMA-like agents are associated with a high serotonin:dopamine transporter-inhibition ratio, whereas more pure amphetamine-like agents have a higher dopamine:serotonin transporter-inhibition ratio

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In the rat model, bidirectional effects on nitric oxide synthases have been observed: stimulation of the endothelial form (eNOS) with simultaneous inhibition of the inducible form (iNOS), suggesting a role in maintaining vascular homeostasis