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doi: 10.3389/fepid.2025.1597799 129 YagiKKondoMTeraiHAsakuraTKimuraRTakemuraRet al

Because glutathione protects cells so well, there is some concern that it could protect the very cells that medical treatments are trying to target

Extensive experimental and computational studies have shown that the binding of GSH to GSTs decreases the p K a of the GSH thiol group from around 9 to about 6 in the active site through hydrogen bonding and salt bridges and through the positive electrostatic potential of the G-site 41,42