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Glucagon receptor activation stimulates hepatic glucose production, increases hepatic lipid oxidation and fatty acid beta-oxidation, and promotes thermogenesis and energy expenditure
J.HagedornC
the glucagon receptor component is hypothesised to help reduce hepatic fat accumulation, though clinical evidence in this area is still emerging [11] [12] Cardiovascular risk weight loss and improved glycaemic control are established contributors to lower cardiovascular risk, but no completed cardiovascular outcomes trial for retatrutide exists
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