21,32,33 Notwithstanding the promising preliminary data in the treatment, prevention, and/or disease modification of SMI-SUD, the evidentiary standard for efficacy has not yet been met, and mixed results have been reported in studies wherein the trial population was enrolled on the basis of having a psychiatric diagnosis

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In contrast, only two studies to date have focused on the pharmacokinetics of mitragynine and other kratom alkaloids in humans (Trakulsrichai et al., 2015