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A scientific review of four small-scale studies confirmed that glutathione use does result in some skin lightening.24 Additionally, glutathione has also been shown to decrease psoriasis when levels are bolstered by intake of whey protein, which contains glutamylcysteine, a precursor to GSH.25 Most impressively, perhaps the same studies mentioned above also show that glutathione doesn't just lighten, but it improves skin elasticity and decreases wrinkles' appearance

Notably, deletion of the equilibrative nucleoside transporter 1 (ENT1) leads to reduced AQP4 expression, further linking purinergic signaling to astrocytic water channel regulation [422]

Liu, Y., Chen, Z., Li, B., Yao, H., Zarka, M., Welch, J., Sachdev, P., Bridge, W., & Braidy, N