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It interacts with multiple pathways, including those regulating angiogenesis, collagen synthesis, and inflammation

Researchers became interested when early studies revealed that these peptides dont just work in parallelthey actually enhance each others mechanisms

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Here, we determine structures of cagrilintide bound to Gs-coupled, active, amylin receptors (AMY 1 R, AMY 2 R, AMY 3 R) and calcitonin receptor (CTR) and compare cagrilintide interactions and the dynamics of receptor complexes with previously reported structures of receptors bound to rat amylin, salmon calcitonin or recently developed amylin-based peptides