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8 The RISE and RIDE (Ranibizumab Injection in Subjects With Clinically Significant Macular Edema With Center Involvement Secondary to Diabetes Mellitus) trials showed that ranibizumab significantly improved vision in patients with DME and reduced diabetic retinopathy severity across all stages

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They reported significant body weight reductions and improvements in several risk factors, including blood pressure, cholesterol, and BMI (body mass index) among participants