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found that the ratio of GSH/GSSG in chondrocytes in elderly patients (age 50) is lower than the ratio of GSH/GSSG in chondrocytes in young patients (age 1849), suggesting that oxidative stress increases with age, which increases the risk of oxidant-mediated cell death in chondrocytes through the imbalance of the glutathione antioxidant system (Carlo and Loeser, 2003)

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Of particular concern is the potential for increased bleeding risk, attributed mainly to ginkgolides platelet-activating factor (PAF) antagonism