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Despite this uniform increase in GFR, variations in renal tubular transport (either secretion or reabsorption) can produce different effects on renally cleared drugs (Muller et al

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JMF4073 eliminates WT-Bcr-Abl-transformed myeloid cells in vitro and in vivo Since the balanced supply of dNTPs is critical for overcoming DNA damage and replication stress for cell survival, we then tested whether JMF4073 treatment could selectively suppress the growth of Bcr-Abl-transformed but not untransformed myeloid cells