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An unexpected effect observed across the class of GLP-1 RAs in almost every study completed to date is their potent effect on weight loss

Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm - 2019 Executive Summary

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Alternative multi-agonists for obesity treatment GLP-1R/GcgR dual agonists have shown impressive metabolic benefits and inspired the search for what now represents a growing class of rationally designed multi-agonists with differentiated mechanisms of action for obesity therapy