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doi: 10.1093/jmcb/mjz005

Genetic ablation of GPX4 induces ferroptosis in multiple mouse cell types, underscoring its indispensable role in cellular redox homeostasis

Under high-glucose conditions, the expression of TREM1 is upregulated, activating the PERK pathway (69)

(senior investigator and chief, Section on the Neurobiology and Treatment of Mood Disorders, Experimental Therapeutics and Pathophysiology Branch, NIMH), is conducting a clinical trial that is examining whether riluzole (an FDA-approved drug for treating amyotrophic lateral sclerosis, also known as ALS or Lou Gehrigs disease) can improve symptoms of depression such as depressed mood, psychomotor retardation, and excessive sleeping in patients with bipolar disorder