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Retatrutide is a once-weekly injection that mimics three hormones involved in appetite, blood sugar, and how the body uses energy: GLP-1: lowers appetite and blood sugar GIP: lowers appetite and blood sugar Glucagon: increases energy expenditure and the breakdown of stored fat, including fat in the liver The glucagon component is what separates retatrutide from semaglutide, which mimics one hormone (GLP-1), and tirzepatide, which mimics two (GLP-1 and GIP)

Indeed, a recent meta-analysis reported that, while proportional to initial loss and varying by type of AOM, weight regain can range from 2.2 kg to 9.7 kg [101]

Comparing the Effectiveness of Ozempic and Mounjaro Ozempic vs Mounjaro: Which is better for weight loss

Mounjaro and Orthostatic Hypotension: Clinical Evidence and Management Mounjaro (tirzepatide) is a dual GIP and GLP-1 receptor agonist licensed in the UK for type 2 diabetes mellitus