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These reactions were dose-dependent, with higher doses producing more frequent and sometimes more pronounced reactions

Animal LD50 studies showed toxic levels around 320 mg/kg body weight, translating to approximately 22,400 mg for a 70 kg human

Oxidative stress can influence drug protein-adduct formation by multiple mechanisms, including induction of conformational alterations or oxidative modifications that can either increase or blunt the reactivity of the modified residues towards the drug, as we have recently reviewed (Gonzlez-Morena et al., 2016)

Neurocognitive deficits in obsessivecompulsive disorder: A selective review