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In a different research, Schwich et al

It has also been shown that BBR is able to inhibit the expression of DNMT1 and DNMT2, as well as prevent methylation of the KLF4 promoter to upregulate KLF4 expression, reduce oxidative stress and expression of ferroptosis markers, rescue renal function in mice with diabetic nephropathy, and prevent renal fibrosis

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