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When GCDH is knocked down in melanoma cells, it leads to increased glutarylation of NRF2, a transcription factor that becomes stabilized and transcriptionally active
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To explain the dependence of slime secretion on the presence of secretins, we consider two plausible mechanisms: secretins could either be directly involved in slime secretion as the OM gates through which the synthesized polymer is secreted, or indirectly by secreting enzymes that then polymerize slime on the cell surface, similar to the synthesis of bacterial dextranes 30
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