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( Metabolites of the kynurenine pathway, 3-HK, and QUIN, are known pro-oxidative metabolites, forming superoxide, hydroxyl radical, and hydrogen peroxide ( 2 O 2 ( We presented the association of oxidative stress with depressive disorder in children and adolescents in a recent paper ( Figure 1 ) is increased and that H 2 O 2 formed during the catalytical reaction can trigger lipoperoxidation and oxidative damage to proteins ( Table 3 )

[DOI] [PubMed] [Google Scholar] 150.Nguyen R.L., Medvedeva Y.V., Ayyagari T.E., Schmunk G., Gargus J.J

NRF2 is known to participate in the regulation of several phase II enzymes, such as heme oxygenase-1 (HO-1) and UDP-glucuronosyltransferase (UGT)

At the same time, clinical understanding of PMOS has broadened, with increasing attention to its metabolic features alongside its reproductive effects