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The total average of the TNF-a concentration quantified in serum in the diabetic cohort was 94,287.52 pg/ml and 31277.37 pg/ml in the healthy control group confirming that the TNF-a titre in rodent serum was increased by 201.4% due to diabetes, comparative to the control group (SMD: 1.11

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Immunosuppression , uncontrolled diabetes, HIV infection, chemotherapy, long-term corticosteroids (including steroid inhalers), and broad-spectrum antibiotics that disturb the normal oral flora