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The researchers commented that the peptide suppressed caspase-dependent apoptosis that increases during aging of cell cultures. By potentially restraining Caspase-3 activity, Epithalon might support cellular longevity and decrease apoptosis, enhancing its regenerative capabilities

Therefore, ketamine cannot be recommended for intravenous regional anesthesia unless these unpleasant side effects are abolished or controlled by means of pharmacologic adjuvants [177]