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eLife 3, e03496

Abstract Skin aging is a multifactorial biological process driven by the cumulative effects of oxidative stress, chronic low-grade inflammation, and progressive deterioration of barrier function

This is why people who start at higher doses or escalate too rapidly report worse nausea

[10] [4] Therefore, any association between semaglutide use and joint symptoms is more likely to be indirect rather than a direct drug effect on articular structures, though this remains an area of ongoing research