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The Phase 3 ENLIGHTEN-Fibrosis trial in non-cirrhotic (F2-F3) MASH and Phase 3 ENLIGHTEN-Cirrhos is trial in compensated cirrhotic (F4) MASH continue to enroll patients, with topline data from the histology cohorts of these trials expected in the first half of 2027 and in 2028, respectively

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These findings are notable in the context of emerging evidence on the role of inflammation and renal glucose handling in postprandial glucose dysregulation

Aneni E et al