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At the core of bone regeneration lies the tightly regulated balance between bone formation and resorption, with osteoblast function serving as a principal determinant of bone-forming capacity ( transcription factor 2 (Runx2 ) and Osterix orchestrate the gene expression programs necessary for osteoblast lineage commitment and functional maturation ( Natural bioactive products derived from TCM can modulate these critical regulatory pathways at multiple levels, thereby facilitating osteogenic differentiation and enhancing bone formation

Yamamoto, N

For example, when pregnant mice were exposed to ZnO nanoparticles, ZnO nanoparticles could pass through the blood-brain barrier, and reach the fetal brain, causing microglial inflammation and eventually leading to nervous system damage in fetal mice