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Most side effects are mild to moderate and diminish over time, but they are real enough to cause treatment discontinuation in 4 to 7% of trial participants [4]

[2] The theoretical basis for transdermal berberine delivery rests on principles of percutaneous absorption, but the practical effectiveness depends on numerous factors including patch formulation, skin characteristics, and importantly, berberine's physicochemical properties

Others find it is an ongoing issue throughout treatment, particularly if dietary fiber and hydration are not adequately addressed

Efficacy and safety of relamorelin in diabetics with symptoms of gastroparesis: a randomized, placebo-controlled study