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But progress was slow and not much happened before Knudsen went on maternity leave (Gilbert, Rosenthal, March 2024)

Laboratory studies using 5-amino-1MQ in aged animal models have revealed that NNMT inhibition modulates many age-associated metabolic parameters, including alterations in muscle tissue metabolism and cellular stress response pathways

All these studies were however performed in non--cell lines, which could carry serious caveats related to cell-type specific patterns of expression of receptors, G proteins, GRKs, and -arrestin isoforms (25), hindering the interpretation of effects related to changes in the engagement of these intertwined regulatory factors

doi: 10.3389/fphys.2014.00091 71 SpreckelmeyerSOrvigCCasiniA