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The effect of intravenous metformin on glucose metabolism during hyperglycaemia in type 2 diabetes

Figure 2 To unravel the precise signaling pathway linking metformin to the NR4A nuclear receptor family requires further studies, but it is worthy of note that the orphan receptor, Nur77, regulates LKB1 localization and is also important for the regulation of glucose uptake into C212 mouse muscle cells (184, 185)