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Regulation of reactive oxygen species generation in cell signaling

Male Wistar rats weighting 220240 g were fed an HFD (Altromin C45, Genestil, Royaucourt, France) for 4 months

Given the multipurpose nature of GLP-1 receptor agonists, the adoption process of these drugs is expected to be significantly accelerated through the continuous emergence of additional clinical evidence

Specifically, ER upregulates nuclear respiratory factor 1 (NRF-1), which in turn stimulates the expression of mitochondrial biogenesis regulators, including mitochondrial transcription factor A (TFAM), and multiple subunits of the mitochondrial respiratory chain (MRC)